Nyamagouda was on the way to his constituency Jamkhandi from Goa when the car he was travelling in tried to avoid a lorry and hit a road side parapet wall, District Superintendent of Police Vamshikumar told PTI.
The 70-year-old lawmaker was in New Delhi and had returned to Goa by flight before he proceeded to his constituency by car, he said.
Nyamagouda had suffered severe injuries and died instantly, he said.
He is survived by wife, two sons and three daughters.
Nyamagouda was the union minister in the P V Narasimha Rao ministry in 1990-91.